{"entity":{"id":"fam174b","kind":"target","name":"FAM174B","aka":["family with sequence similarity 174 member B","Membrane protein FAM174B","LOC400451","MGC102891"],"tldr":"FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.","summary":"Essential for Golgi structural integrity.\n\nIntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:34339","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:34339"},{"label":"UniProt Q3ZCQ3","url":"https://www.uniprot.org/uniprotkb/Q3ZCQ3/entry"},{"label":"NCBI Gene 400451","url":"https://www.ncbi.nlm.nih.gov/gene/400451"},{"label":"Ensembl ENSG00000185442","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185442"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate","medulloblastoma","paediatric-low-grade-glioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAM174B","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:34339","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:34339","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q3ZCQ3","url":"https://www.uniprot.org/uniprotkb/Q3ZCQ3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FAM174B","url":"https://www.intogen.org/search?gene=FAM174B","note":"driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:34339","ensembl":"ENSG00000185442","uniprot":"Q3ZCQ3","entrez":"400451","biology":"Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt). Locus 15q26.1 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Medulloblastoma: IntOGen driver in 1 cohort (MBL)","Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/fam174b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}