{"entity":{"id":"fancb","kind":"target","name":"FANCB","aka":["FA complementation group B","Fanconi anemia group B protein","FLJ34064","FAAP95"],"tldr":"FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"DNA repair protein required for FANCD2 ubiquitination.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.18, genetic literature 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3583","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3583"},{"label":"UniProt Q8NB91","url":"https://www.uniprot.org/uniprotkb/Q8NB91/entry"},{"label":"NCBI Gene 2187","url":"https://www.ncbi.nlm.nih.gov/gene/2187"},{"label":"Ensembl ENSG00000181544","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181544"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCB","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3583","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3583","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NB91","url":"https://www.uniprot.org/uniprotkb/Q8NB91/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000181544","url":"https://platform.opentargets.org/target/ENSG00000181544/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3583","ensembl":"ENSG00000181544","uniprot":"Q8NB91","entrez":"2187","biology":"DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fancb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}