{"entity":{"id":"fance","kind":"target","name":"FANCE","aka":["FA complementation group E","Fanconi anemia group E protein"],"tldr":"FANCE (Fanconi anaemia group E protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Myeloproliferative neoplasms and 2 more.","summary":"As part of the Fanconi anaemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.74, somatic mutation 0.95, genetic literature 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3586","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3586"},{"label":"UniProt Q9HB96","url":"https://www.uniprot.org/uniprotkb/Q9HB96/entry"},{"label":"NCBI Gene 2178","url":"https://www.ncbi.nlm.nih.gov/gene/2178"},{"label":"Ensembl ENSG00000112039","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112039"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","colorectal","myeloproliferative-neoplasms","skin-cancer","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCE","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3586","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3586","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HB96","url":"https://www.uniprot.org/uniprotkb/Q9HB96/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000112039","url":"https://platform.opentargets.org/target/ENSG00000112039/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.54, acute myeloid leukaemia 0.53, skin cancer 0.51, myeloproliferative neoplasm 0.53, leukaemia 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:3586","ensembl":"ENSG00000112039","uniprot":"Q9HB96","entrez":"2178","biology":"As part of the Fanconi anaemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Location: Nucleus (UniProt). Locus 6p21.31 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)","Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Acute myeloid leukaemia: Open Targets association 0.53 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"other","prevalence":[]},"route":"/targets/fance/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}