{"entity":{"id":"fancf","kind":"target","name":"FANCF","aka":["FA complementation group F","Fanconi anemia group F protein"],"tldr":"FANCF (Fanconi anaemia group F protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Skin cancer and Melanoma.","summary":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.83, affected pathway 0.26, literature 0.94, genetic association 0.25, somatic mutation 0.93, animal model 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3587","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3587"},{"label":"UniProt Q9NPI8","url":"https://www.uniprot.org/uniprotkb/Q9NPI8/entry"},{"label":"NCBI Gene 2188","url":"https://www.ncbi.nlm.nih.gov/gene/2188"},{"label":"Ensembl ENSG00000183161","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183161"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCF","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3587","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3587","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NPI8","url":"https://www.uniprot.org/uniprotkb/Q9NPI8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000183161","url":"https://platform.opentargets.org/target/ENSG00000183161/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.50, leukaemia 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:3587","ensembl":"ENSG00000183161","uniprot":"Q9NPI8","entrez":"2188","biology":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Location: Nucleus (UniProt). Locus 11p14.3 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/fancf/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}