{"entity":{"id":"fancg","kind":"target","name":"FANCG","aka":["FA complementation group G","Fanconi anemia group G protein","XRCC9"],"tldr":"FANCG (Fanconi anaemia group G protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Colorectal cancer and 2 more.","summary":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.83, literature 0.90, genetic association 0.60, somatic mutation 0.96, animal model 0.35).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3588"},{"label":"UniProt O15287","url":"https://www.uniprot.org/uniprotkb/O15287/entry"},{"label":"NCBI Gene 2189","url":"https://www.ncbi.nlm.nih.gov/gene/2189"},{"label":"Ensembl ENSG00000221829","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221829"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","colorectal","lung-cancer","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCG","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3588","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15287","url":"https://www.uniprot.org/uniprotkb/O15287/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000221829","url":"https://platform.opentargets.org/target/ENSG00000221829/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.52, acute myeloid leukaemia 0.54, myeloproliferative neoplasm 0.54, lung cancer 0.51, leukaemia 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:3588","ensembl":"ENSG00000221829","uniprot":"O15287","entrez":"2189","biology":"DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene. Location: Nucleus; Cytoplasm (UniProt). Locus 9p13.3 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076)","Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Acute myeloid leukaemia: Open Targets association 0.54 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"other","prevalence":[]},"route":"/targets/fancg/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}