{"entity":{"id":"fanci","kind":"target","name":"FANCI","aka":["FA complementation group I","Fanconi anemia group I protein","FLJ10719","KIAA1794"],"tldr":"FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.30, genetic association 0.50, genetic literature 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25568","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25568"},{"label":"UniProt Q9NVI1","url":"https://www.uniprot.org/uniprotkb/Q9NVI1/entry"},{"label":"NCBI Gene 55215","url":"https://www.ncbi.nlm.nih.gov/gene/55215"},{"label":"Ensembl ENSG00000140525","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140525"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCI","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:25568","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25568","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NVI1","url":"https://www.uniprot.org/uniprotkb/Q9NVI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140525","url":"https://platform.opentargets.org/target/ENSG00000140525/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:25568","ensembl":"ENSG00000140525","uniprot":"Q9NVI1","entrez":"55215","biology":"Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fanci/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}