{"entity":{"id":"fancm","kind":"target","name":"FANCM","aka":["FA complementation group M","Fanconi anemia group M protein","FAAP250","KIAA1596"],"tldr":"FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.","summary":"DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.33, affected pathway 0.31, literature 0.67, genetic association 0.88, animal model 0.44).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23168"},{"label":"UniProt Q8IYD8","url":"https://www.uniprot.org/uniprotkb/Q8IYD8/entry"},{"label":"NCBI Gene 57697","url":"https://www.ncbi.nlm.nih.gov/gene/57697"},{"label":"Ensembl ENSG00000187790","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187790"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCM","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23168","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IYD8","url":"https://www.uniprot.org/uniprotkb/Q8IYD8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000187790","url":"https://platform.opentargets.org/target/ENSG00000187790/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: ovarian cancer 0.53, breast cancer 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:23168","ensembl":"ENSG00000187790","uniprot":"Q8IYD8","entrez":"57697","biology":"DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. Location: Nucleus (UniProt). Locus 14q21.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.53 with ovarian cancer (MONDO_0008170)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/fancm/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}