{"entity":{"id":"fas","kind":"target","name":"FAS","aka":["Fas cell surface death receptor","Tumor necrosis factor receptor superfamily member 6","CD95","APO-1","FAS1","APT1","TNFRSF6"],"tldr":"FAS (Tumour necrosis factor receptor superfamily member 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Cervical cancer and 5 more.","summary":"Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.99, animal model 0.59, genetic association 0.18, somatic mutation 0.78). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cervical Squamous Cell Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11920","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11920"},{"label":"UniProt P25445","url":"https://www.uniprot.org/uniprotkb/P25445/entry"},{"label":"NCBI Gene 355","url":"https://www.ncbi.nlm.nih.gov/gene/355"},{"label":"Ensembl ENSG00000026103","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000026103"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","leukaemia","cervical","skin-cancer","dlbcl","melanoma","marginal-zone-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["extrinsic-apoptosis-death-receptors"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAS","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11920","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11920","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25445","url":"https://www.uniprot.org/uniprotkb/P25445/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FAS","url":"https://civicdb.org/features/375","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000026103","url":"https://platform.opentargets.org/target/ENSG00000026103/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.52, acute lymphoblastic leukaemia 0.50, diffuse large B-cell lymphoma 0.59, non-Hodgkin lymphoma 0.71, skin cancer 0.52, leukaemia 0.63 (GraphQL API, CC0)"},{"label":"IntOGen FAS","url":"https://www.intogen.org/search?gene=FAS","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11920","ensembl":"ENSG00000026103","uniprot":"P25445","entrez":"355","biology":"Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Location: Cell membrane; Membrane raft; Secreted (UniProt). Locus 10q23.31 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.71 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 1 cohort (MLYM)","Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059)","Cervical cancer: IntOGen driver in 1 cohort (CESC)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Diffuse large B-cell lymphoma: Open Targets association 0.59 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fas/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"marginal-zone-lymphoma","kind":"cancer","name":"Marginal zone lymphoma","route":"/cancers/marginal-zone-lymphoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"extrinsic-apoptosis-death-receptors","kind":"pathway","name":"Extrinsic apoptosis (death receptors)","route":"/pathways/extrinsic-apoptosis-death-receptors/"}]}}