{"entity":{"id":"fat1","kind":"target","name":"FAT1","aka":["FAT atypical cadherin 1","Protocadherin Fat 1","CDHF7","CDHR8"],"tldr":"FAT1 (Protocadherin Fat 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Lung cancer, Bladder & urothelial cancer and 5 more.","summary":"Plays an essential role for cellular polarisation, directed cell migration and modulating cell-cell contact.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming CDK4/6 Inhibition. Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes affected pathway 0.61, literature 0.99, genetic association 0.18, somatic mutation 0.98, animal model 0.44). IntOGen calls it a driver in 45 cohorts (15 activating, 30 loss-of-function), covering Acute Myeloid Leukaemia, Angiosarcoma, Anal Squamous Cell Carcinoma, Basal Cell Carcinoma, Burkitt Lymphoma, Bladder/Urinary Tract and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3595"},{"label":"UniProt Q14517","url":"https://www.uniprot.org/uniprotkb/Q14517/entry"},{"label":"NCBI Gene 2195","url":"https://www.ncbi.nlm.nih.gov/gene/2195"},{"label":"Ensembl ENSG00000083857","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000083857"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["head-and-neck","lung-cancer","urothelial","breast-cancer","esophageal","cervical","nasopharyngeal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 15 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 30 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAT1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3595","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14517","url":"https://www.uniprot.org/uniprotkb/Q14517/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FAT1","url":"https://civicdb.org/features/1827","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000083857","url":"https://platform.opentargets.org/target/ENSG00000083857/associations","note":"association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, colorectal cancer 0.59, oesophageal cancer 0.59, urinary bladder cancer 0.60, cervical cancer 0.53, melanoma 0.62 (GraphQL API, CC0)"},{"label":"IntOGen FAT1","url":"https://www.intogen.org/search?gene=FAT1","note":"driver in 45 cohorts (Act 15, LoF 30); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3595","ensembl":"ENSG00000083857","uniprot":"Q14517","entrez":"2195","biology":"Plays an essential role for cellular polarisation, directed cell migration and modulating cell-cell contact. Location: Cell membrane; Nucleus (UniProt). Locus 4q35.2 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: Open Targets association 0.70 with head and neck squamous cell carcinoma (MONDO_0010150); IntOGen driver in 5 cohorts (HNSC)","Lung cancer: Open Targets association 0.68 with lung cancer (MONDO_0008903)","Bladder & urothelial cancer: Open Targets association 0.60 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 7 cohorts (BLADDER, BLCA, UTUC)","Breast cancer: CIViC evidence names this disease; IntOGen driver in 1 cohort (BRCA)","Oesophageal cancer: Open Targets association 0.59 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA, ESCC)","Cervical cancer: Open Targets association 0.53 with cervical cancer (MONDO_0002974); IntOGen driver in 2 cohorts (CESC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fat1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}