{"entity":{"id":"fat2","kind":"target","name":"FAT2","aka":["FAT atypical cadherin 2","Protocadherin Fat 2","MEGF1","CDHF8","HFAT2","CDHR9"],"tldr":"FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.","summary":"Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Vulva/Vagina.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3596","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3596"},{"label":"UniProt Q9NYQ8","url":"https://www.uniprot.org/uniprotkb/Q9NYQ8/entry"},{"label":"NCBI Gene 2196","url":"https://www.ncbi.nlm.nih.gov/gene/2196"},{"label":"Ensembl ENSG00000086570","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086570"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["vulvar"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAT2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3596","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3596","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NYQ8","url":"https://www.uniprot.org/uniprotkb/Q9NYQ8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FAT2","url":"https://www.intogen.org/search?gene=FAT2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3596","ensembl":"ENSG00000086570","uniprot":"Q9NYQ8","entrez":"2196","biology":"Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development. Location: Cell membrane; Cell junction; Golgi apparatus, trans-Golgi network (UniProt). Locus 5q33.1 (HGNC).","whereFound":["Vulvar cancer: IntOGen driver in 1 cohort (VULVA)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fat2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"vulvar","kind":"cancer","name":"Vulvar cancer","route":"/cancers/vulvar/"}]}}