{"entity":{"id":"fat3","kind":"target","name":"FAT3","aka":["FAT atypical cadherin 3","Protocadherin Fat 3","KIAA1989","CDHF15","CDHR10"],"tldr":"FAT3 (Protocadherin Fat 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Pancreatic ductal adenocarcinoma, Renal cell carcinoma and 5 more.","summary":"May play a role in the interactions between neurites derived from specific subsets of neurons during development.\n\nIntOGen calls it a driver in 29 cohorts (22 activating, 7 loss-of-function), covering Angiosarcoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Colon Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23112"},{"label":"UniProt Q8TDW7","url":"https://www.uniprot.org/uniprotkb/Q8TDW7/entry"},{"label":"NCBI Gene 120114","url":"https://www.ncbi.nlm.nih.gov/gene/120114"},{"label":"Ensembl ENSG00000165323","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165323"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["breast-cancer","pancreatic","rcc","colorectal","prostate","gastric","head-and-neck","neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 22 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 7 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAT3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:23112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23112","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TDW7","url":"https://www.uniprot.org/uniprotkb/Q8TDW7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FAT3","url":"https://www.intogen.org/search?gene=FAT3","note":"driver in 29 cohorts (Act 22, LoF 7); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:23112","ensembl":"ENSG00000165323","uniprot":"Q8TDW7","entrez":"120114","biology":"May play a role in the interactions between neurites derived from specific subsets of neurons during development. Location: Membrane (UniProt). Locus 11q14.3 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 4 cohorts (BRCA)","Pancreatic ductal adenocarcinoma: IntOGen driver in 3 cohorts (PAAD, PANCREAS)","Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC, RCC)","Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)","Prostate cancer: IntOGen driver in 2 cohorts (PRAD)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 2 cohorts (STAD, STOMACH)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/fat3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}