{"entity":{"id":"fat4","kind":"target","name":"FAT4","aka":["FAT atypical cadherin 4","Protocadherin Fat 4","CDHF14","FAT-J","CDHR11"],"tldr":"FAT4 (Protocadherin Fat 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Colorectal cancer, Hepatocellular carcinoma and 5 more.","summary":"Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.97, animal model 0.39, genetic association 0.36, somatic mutation 0.90). IntOGen calls it a driver in 37 cohorts (24 activating, 12 loss-of-function), covering Adrenocortical Carcinoma, Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Anal Squamous Cell Carcinoma, Basal Cell Carcinoma, Invasive Breast Carcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23109","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23109"},{"label":"UniProt Q6V0I7","url":"https://www.uniprot.org/uniprotkb/Q6V0I7/entry"},{"label":"NCBI Gene 79633","url":"https://www.ncbi.nlm.nih.gov/gene/79633"},{"label":"Ensembl ENSG00000196159","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196159"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate","colorectal","hcc","breast-cancer","gastric","esophageal","mesothelioma","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 24 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 12 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAT4","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:23109","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23109","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6V0I7","url":"https://www.uniprot.org/uniprotkb/Q6V0I7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196159","url":"https://platform.opentargets.org/target/ENSG00000196159/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.62, gastric cancer 0.56, oesophageal cancer 0.50, ovarian cancer 0.52, melanoma 0.60, non-Hodgkin lymphoma 0.52 (GraphQL API, CC0)"},{"label":"IntOGen FAT4","url":"https://www.intogen.org/search?gene=FAT4","note":"driver in 37 cohorts (Act 24, LoF 12); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:23109","ensembl":"ENSG00000196159","uniprot":"Q6V0I7","entrez":"79633","biology":"Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Location: Membrane (UniProt). Locus 4q28.1 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 4 cohorts (PRAD)","Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)","Hepatocellular carcinoma: IntOGen driver in 3 cohorts (HCC)","Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.56 with gastric cancer (MONDO_0001056); IntOGen driver in 2 cohorts (STAD, STOMACH)","Oesophageal cancer: Open Targets association 0.50 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/fat4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}