{"entity":{"id":"fbln2","kind":"target","name":"FBLN2","aka":["fibulin 2","Fibulin-2"],"tldr":"FBLN2 (Fibulin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Bladder & urothelial cancer, Hepatocellular carcinoma and 4 more.","summary":"Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.\n\nIntOGen calls it a driver in 8 cohorts (2 activating, 5 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma, Neuroblastoma, Pancreatic Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3601","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3601"},{"label":"UniProt P98095","url":"https://www.uniprot.org/uniprotkb/P98095/entry"},{"label":"NCBI Gene 2199","url":"https://www.ncbi.nlm.nih.gov/gene/2199"},{"label":"Ensembl ENSG00000163520","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163520"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic","urothelial","hcc","head-and-neck","prostate","cholangiocarcinoma","neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FBLN2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3601","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3601","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P98095","url":"https://www.uniprot.org/uniprotkb/P98095/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FBLN2","url":"https://www.intogen.org/search?gene=FBLN2","note":"driver in 8 cohorts (Act 2, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3601","ensembl":"ENSG00000163520","uniprot":"P98095","entrez":"2199","biology":"Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 3p25.1 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 2 cohorts (PAAD)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fbln2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}