{"entity":{"id":"fbxo11","kind":"target","name":"FBXO11","aka":["F-box protein 11","F-box only protein 11","FBX11","UBR6"],"tldr":"FBXO11 (F-box only protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Endometrial cancer, Ovarian cancer and 5 more.","summary":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal centre B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signalling, cell migration and the timing of the cell-cycle progression and exit.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.83 (direct and indirect evidence; datatypes literature 0.96, animal model 0.49, genetic association 0.87, somatic mutation 0.97). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Burkitt Lymphoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13590","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13590"},{"label":"UniProt Q86XK2","url":"https://www.uniprot.org/uniprotkb/Q86XK2/entry"},{"label":"NCBI Gene 80204","url":"https://www.ncbi.nlm.nih.gov/gene/80204"},{"label":"Ensembl ENSG00000138081","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138081"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["colorectal","endometrial","ovarian","breast-cancer","gastric","non-hodgkin-lymphoma","prostate","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FBXO11","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13590","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13590","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86XK2","url":"https://www.uniprot.org/uniprotkb/Q86XK2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FBXO11","url":"https://civicdb.org/features/15318","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000138081","url":"https://platform.opentargets.org/target/ENSG00000138081/associations","note":"association with cancer (MONDO_0004992) 0.83; per-cancer scores at or above 0.5: colorectal cancer 0.79, gastric cancer 0.65, prostate cancer 0.60, ovarian cancer 0.72, endometrial cancer 0.74, melanoma 0.52 (GraphQL API, CC0)"},{"label":"IntOGen FBXO11","url":"https://www.intogen.org/search?gene=FBXO11","note":"driver in 5 cohorts (Act 1, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13590","ensembl":"ENSG00000138081","uniprot":"Q86XK2","entrez":"80204","biology":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal centre B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signalling, cell migration and the timing of the cell-cycle progression and exit. The SCF(FBXO11) complex also catalyses ubiquitination and degradation of GSK3B-phosphorylated SNAI1. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Location: Nucleus; Chromosome (UniProt). Locus 2p16.3 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.79 with colorectal cancer (MONDO_0005575)","Endometrial cancer: Open Targets association 0.74 with endometrial cancer (MONDO_0011962)","Ovarian cancer: Open Targets association 0.72 with ovarian cancer (MONDO_0008170)","Breast cancer: Open Targets association 0.69 with breast cancer (MONDO_0007254)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.65 with gastric cancer (MONDO_0001056)","Non-Hodgkin lymphoma: Open Targets association 0.62 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (MLYM, NHL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fbxo11/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}