{"entity":{"id":"fbxw11","kind":"target","name":"FBXW11","aka":["F-box and WD repeat domain containing 11","F-box/WD repeat-containing protein 11","KIAA0696","Fbw1b","BTRCP2","BTRC2","Hos","Fbw11","FBXW1B"],"tldr":"FBXW11 (F-box/WD repeat-containing protein 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13607"},{"label":"UniProt Q9UKB1","url":"https://www.uniprot.org/uniprotkb/Q9UKB1/entry"},{"label":"NCBI Gene 23291","url":"https://www.ncbi.nlm.nih.gov/gene/23291"},{"label":"Ensembl ENSG00000072803","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072803"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Salivary Gland Basal Cell Adenoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FBXW11","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13607","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UKB1","url":"https://www.uniprot.org/uniprotkb/Q9UKB1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FBXW11","url":"https://civicdb.org/features/9443","note":"1 evidence items, 0 assertions, 1 variants; diseases: Salivary Gland Basal Cell Adenoma (GraphQL API, CC0)"}],"hgnc":"HGNC:13607","ensembl":"ENSG00000072803","uniprot":"Q9UKB1","entrez":"23291","biology":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Location: Cytoplasm; Nucleus (UniProt). Locus 5q35.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fbxw11/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}