{"entity":{"id":"fcrl4","kind":"target","name":"FCRL4","aka":["Fc receptor like 4","Fc receptor-like protein 4","FCRH4","IRTA1","IGFP2","CD307d"],"tldr":"FCRL4 (Fc receptor-like protein 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Skin cancer, Lung cancer and 2 more.","summary":"May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.39, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18507","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18507"},{"label":"UniProt Q96PJ5","url":"https://www.uniprot.org/uniprotkb/Q96PJ5/entry"},{"label":"NCBI Gene 83417","url":"https://www.ncbi.nlm.nih.gov/gene/83417"},{"label":"Ensembl ENSG00000163518","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163518"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["pancreatic","skin-cancer","lung-cancer","breast-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FCRL4","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18507","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18507","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96PJ5","url":"https://www.uniprot.org/uniprotkb/Q96PJ5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163518","url":"https://platform.opentargets.org/target/ENSG00000163518/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.56, breast cancer 0.51, lung cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen FCRL4","url":"https://www.intogen.org/search?gene=FCRL4","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18507","ensembl":"ENSG00000163518","uniprot":"Q96PJ5","entrez":"83417","biology":"May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response. Location: Cell membrane (UniProt). Locus 1q23.1 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fcrl4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}