{"entity":{"id":"ferumoxtran-10","kind":"drug","name":"Ferumoxtran-10 (Sinerem, lymph node MRI contrast)","aka":["ferumoxtran-10","Sinerem","iron oxide nanoparticles"],"tldr":"An iron-based MRI dye designed to show whether lymph nodes contain cancer. Its European application was withdrawn in 2007 and it is not authorised there.","summary":"The EMA register lists Sinerem (iron oxide, Guerbet, EMEA/H/C/000801) with the status \"Application withdrawn\", the withdrawal dated 13 December 2007. The WHO index lists iron oxide nanoparticles as ATC V08CB03 among superparamagnetic contrast media.","status":"withdrawn","asOf":"2026-11-04","links":[{"label":"EMA: Sinerem","url":"https://www.ema.europa.eu/en/medicines/human/EPAR/sinerem"},{"label":"WHO ATC index V08CB: superparamagnetic contrast media","url":"https://atcddd.fhi.no/atc_ddd_index/?code=V08CB&showdescription=no"}],"tags":["contrast-agents-gaps-2026-11","diagnostic"],"related":[],"cancers":[],"sections":[],"technologies":["mri","gadolinium-based-contrast-agents"],"targets":[],"drugs":[],"companies":["guerbet"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo contrast agent gap fill (Drugs@FDA, FDA labels, DailyMed, EMA register, WHO ATC index)","editedOn":"2026-11-04"},"brand":"Sinerem","modality":"Iron oxide nanoparticle contrast agent for lymph node MRI (application withdrawn in Europe)","mechanism":"Ultrasmall iron oxide nanoparticles, a superparamagnetic contrast medium, change the MRI signal of tissues that take them up; the product was developed to image lymph nodes.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ferumoxtran-10/","neighbours":{"technology":[{"id":"gadolinium-based-contrast-agents","kind":"technology","name":"Gadolinium-based and other MRI contrast agents","route":"/technologies/gadolinium-based-contrast-agents/"},{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"}],"company":[{"id":"guerbet","kind":"company","name":"Guerbet","route":"/companies/guerbet/"}]}}