{"entity":{"id":"fev","kind":"target","name":"FEV","aka":["FEV transcription factor, ETS family member","Pet-1"],"tldr":"FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.67, genetic association 0.00, somatic mutation 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18562","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18562"},{"label":"UniProt Q99581","url":"https://www.uniprot.org/uniprotkb/Q99581/entry"},{"label":"NCBI Gene 54738","url":"https://www.ncbi.nlm.nih.gov/gene/54738"},{"label":"Ensembl ENSG00000163497","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163497"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FEV","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18562","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18562","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99581","url":"https://www.uniprot.org/uniprotkb/Q99581/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163497","url":"https://platform.opentargets.org/target/ENSG00000163497/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18562","ensembl":"ENSG00000163497","uniprot":"Q99581","entrez":"54738","biology":"Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Location: Nucleus (UniProt). Locus 2q35 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/fev/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}