{"entity":{"id":"fgd1","kind":"target","name":"FGD1","aka":["FYVE, RhoGEF and PH domain containing 1","FYVE, RhoGEF and PH domain-containing protein 1","ZFYVE3"],"tldr":"FGD1 (FYVE, RhoGEF and PH domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.","summary":"Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3663","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3663"},{"label":"UniProt P98174","url":"https://www.uniprot.org/uniprotkb/P98174/entry"},{"label":"NCBI Gene 2245","url":"https://www.ncbi.nlm.nih.gov/gene/2245"},{"label":"Ensembl ENSG00000102302","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102302"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGD1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3663","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3663","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P98174","url":"https://www.uniprot.org/uniprotkb/P98174/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FGD1","url":"https://www.intogen.org/search?gene=FGD1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3663","ensembl":"ENSG00000102302","uniprot":"P98174","entrez":"2245","biology":"Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm; Cell projection, lamellipodium; Cell projection, ruffle; Cytoplasm, cytoskeleton (UniProt). Locus Xp11.22 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/fgd1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}