{"entity":{"id":"fgf10","kind":"target","name":"FGF10","aka":["fibroblast growth factor 10","Fibroblast growth factor 10"],"tldr":"FGF10 (Fibroblast growth factor 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.91, genetic association 0.78, somatic mutation 0.61, animal model 0.90).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3666","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3666"},{"label":"UniProt O15520","url":"https://www.uniprot.org/uniprotkb/O15520/entry"},{"label":"NCBI Gene 2255","url":"https://www.ncbi.nlm.nih.gov/gene/2255"},{"label":"Ensembl ENSG00000070193","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070193"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3666","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3666","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15520","url":"https://www.uniprot.org/uniprotkb/O15520/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000070193","url":"https://platform.opentargets.org/target/ENSG00000070193/associations","note":"association with cancer (MONDO_0004992) 0.76;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3666","ensembl":"ENSG00000070193","uniprot":"O15520","entrez":"2255","biology":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Location: Secreted (UniProt). Locus 5p12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}