{"entity":{"id":"fgf16","kind":"target","name":"FGF16","aka":["fibroblast growth factor 16","Fibroblast growth factor 16","MF4"],"tldr":"FGF16 (Fibroblast growth factor 16) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3672","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3672"},{"label":"UniProt O43320","url":"https://www.uniprot.org/uniprotkb/O43320/entry"},{"label":"NCBI Gene 8823","url":"https://www.ncbi.nlm.nih.gov/gene/8823"},{"label":"Ensembl ENSG00000196468","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196468"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF16","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3672","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3672","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43320","url":"https://www.uniprot.org/uniprotkb/O43320/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196468","url":"https://platform.opentargets.org/target/ENSG00000196468/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3672","ensembl":"ENSG00000196468","uniprot":"O43320","entrez":"8823","biology":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Location: Secreted (UniProt). Locus Xq21.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf16/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}