{"entity":{"id":"fgf17","kind":"target","name":"FGF17","aka":["fibroblast growth factor 17","Fibroblast growth factor 17","FGF-13"],"tldr":"FGF17 (Fibroblast growth factor 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of embryonic development and as signalling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.98, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3673","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3673"},{"label":"UniProt O60258","url":"https://www.uniprot.org/uniprotkb/O60258/entry"},{"label":"NCBI Gene 8822","url":"https://www.ncbi.nlm.nih.gov/gene/8822"},{"label":"Ensembl ENSG00000158815","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158815"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF17","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3673","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3673","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60258","url":"https://www.uniprot.org/uniprotkb/O60258/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000158815","url":"https://platform.opentargets.org/target/ENSG00000158815/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3673","ensembl":"ENSG00000158815","uniprot":"O60258","entrez":"8822","biology":"Plays an important role in the regulation of embryonic development and as signalling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Location: Secreted (UniProt). Locus 8p21.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf17/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}