{"entity":{"id":"fgf18","kind":"target","name":"FGF18","aka":["fibroblast growth factor 18","Fibroblast growth factor 18","FGF-18","ZFGF5"],"tldr":"FGF18 (Fibroblast growth factor 18) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.98, animal model 0.51, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3674","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3674"},{"label":"UniProt O76093","url":"https://www.uniprot.org/uniprotkb/O76093/entry"},{"label":"NCBI Gene 8817","url":"https://www.ncbi.nlm.nih.gov/gene/8817"},{"label":"Ensembl ENSG00000156427","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156427"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF18","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3674","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3674","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O76093","url":"https://www.uniprot.org/uniprotkb/O76093/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156427","url":"https://platform.opentargets.org/target/ENSG00000156427/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3674","ensembl":"ENSG00000156427","uniprot":"O76093","entrez":"8817","biology":"Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Location: Secreted (UniProt). Locus 5q35.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf18/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}