{"entity":{"id":"fgf22","kind":"target","name":"FGF22","aka":["fibroblast growth factor 22","Fibroblast growth factor 22"],"tldr":"FGF22 (Fibroblast growth factor 22) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.36, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3679","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3679"},{"label":"UniProt Q9HCT0","url":"https://www.uniprot.org/uniprotkb/Q9HCT0/entry"},{"label":"NCBI Gene 27006","url":"https://www.ncbi.nlm.nih.gov/gene/27006"},{"label":"Ensembl ENSG00000070388","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070388"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF22","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3679","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3679","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCT0","url":"https://www.uniprot.org/uniprotkb/Q9HCT0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000070388","url":"https://platform.opentargets.org/target/ENSG00000070388/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3679","ensembl":"ENSG00000070388","uniprot":"Q9HCT0","entrez":"27006","biology":"Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Location: Secreted (UniProt). Locus 19p13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf22/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}