{"entity":{"id":"fgf3","kind":"target","name":"FGF3","aka":["fibroblast growth factor 3","Fibroblast growth factor 3","HBGF-3","INT2"],"tldr":"FGF3 (Fibroblast growth factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Hepatocellular carcinoma.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Sorafenib and Dovitinib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.49, affected pathway 0.92, animal model 0.25, genetic association 0.13).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3681"},{"label":"UniProt P11487","url":"https://www.uniprot.org/uniprotkb/P11487/entry"},{"label":"NCBI Gene 2248","url":"https://www.ncbi.nlm.nih.gov/gene/2248"},{"label":"Ensembl ENSG00000186895","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186895"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["breast-cancer","hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3681","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11487","url":"https://www.uniprot.org/uniprotkb/P11487/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FGF3","url":"https://civicdb.org/features/1873","note":"3 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Hepatocellular Carcinoma, Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000186895","url":"https://platform.opentargets.org/target/ENSG00000186895/associations","note":"association with cancer (MONDO_0004992) 0.66;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3681","ensembl":"ENSG00000186895","uniprot":"P11487","entrez":"2248","biology":"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease","Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/fgf3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}