{"entity":{"id":"fgf4","kind":"target","name":"FGF4","aka":["fibroblast growth factor 4","Fibroblast growth factor 4","K-FGF","HBGF-4","HST-1","HSTF1"],"tldr":"FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Sorafenib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.40, affected pathway 0.94, genetic association 0.05).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3682"},{"label":"UniProt P08620","url":"https://www.uniprot.org/uniprotkb/P08620/entry"},{"label":"NCBI Gene 2249","url":"https://www.ncbi.nlm.nih.gov/gene/2249"},{"label":"Ensembl ENSG00000075388","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075388"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF4","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3682","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08620","url":"https://www.uniprot.org/uniprotkb/P08620/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FGF4","url":"https://civicdb.org/features/1874","note":"4 evidence items, 0 assertions, 2 variants; diseases: Cancer, Hepatocellular Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000075388","url":"https://platform.opentargets.org/target/ENSG00000075388/associations","note":"association with cancer (MONDO_0004992) 0.66;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3682","ensembl":"ENSG00000075388","uniprot":"P08620","entrez":"2249","biology":"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/fgf4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}