{"entity":{"id":"fgf5","kind":"target","name":"FGF5","aka":["fibroblast growth factor 5","Fibroblast growth factor 5"],"tldr":"FGF5 (Fibroblast growth factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.91, affected pathway 0.98, animal model 0.59, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3683"},{"label":"UniProt P12034","url":"https://www.uniprot.org/uniprotkb/P12034/entry"},{"label":"NCBI Gene 2250","url":"https://www.ncbi.nlm.nih.gov/gene/2250"},{"label":"Ensembl ENSG00000138675","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138675"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3683","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P12034","url":"https://www.uniprot.org/uniprotkb/P12034/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138675","url":"https://platform.opentargets.org/target/ENSG00000138675/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3683","ensembl":"ENSG00000138675","uniprot":"P12034","entrez":"2250","biology":"Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Location: Secreted (UniProt). Locus 4q21.21 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}