{"entity":{"id":"fgf6","kind":"target","name":"FGF6","aka":["fibroblast growth factor 6","Fibroblast growth factor 6"],"tldr":"FGF6 (Fibroblast growth factor 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.33, affected pathway 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3684"},{"label":"UniProt P10767","url":"https://www.uniprot.org/uniprotkb/P10767/entry"},{"label":"NCBI Gene 2251","url":"https://www.ncbi.nlm.nih.gov/gene/2251"},{"label":"Ensembl ENSG00000111241","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111241"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF6","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3684","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10767","url":"https://www.uniprot.org/uniprotkb/P10767/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000111241","url":"https://platform.opentargets.org/target/ENSG00000111241/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3684","ensembl":"ENSG00000111241","uniprot":"P10767","entrez":"2251","biology":"Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Location: Secreted, extracellular space (UniProt). Locus 12p13.32 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}