{"entity":{"id":"fgf7","kind":"target","name":"FGF7","aka":["fibroblast growth factor 7","Fibroblast growth factor 7"],"tldr":"FGF7 (Fibroblast growth factor 7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, animal model 0.55, genetic association 0.45). In OnCo, 1 product record names it (Palifermin).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3685","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3685"},{"label":"UniProt P21781","url":"https://www.uniprot.org/uniprotkb/P21781/entry"},{"label":"NCBI Gene 2252","url":"https://www.ncbi.nlm.nih.gov/gene/2252"},{"label":"Ensembl ENSG00000140285","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140285"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["palifermin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF7","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3685","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3685","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21781","url":"https://www.uniprot.org/uniprotkb/P21781/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140285","url":"https://platform.opentargets.org/target/ENSG00000140285/associations","note":"association with cancer (MONDO_0004992) 0.69;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3685","ensembl":"ENSG00000140285","uniprot":"P21781","entrez":"2252","biology":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Location: Secreted (UniProt). Locus 15q21.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"drug":[{"id":"palifermin","kind":"drug","name":"Palifermin","route":"/drugs/palifermin/"}]}}