{"entity":{"id":"fgf8","kind":"target","name":"FGF8","aka":["fibroblast growth factor 8","Fibroblast growth factor 8"],"tldr":"FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.98, animal model 0.30, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3686"},{"label":"UniProt P55075","url":"https://www.uniprot.org/uniprotkb/P55075/entry"},{"label":"NCBI Gene 2253","url":"https://www.ncbi.nlm.nih.gov/gene/2253"},{"label":"Ensembl ENSG00000107831","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107831"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF8","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3686","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3686","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55075","url":"https://www.uniprot.org/uniprotkb/P55075/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000107831","url":"https://platform.opentargets.org/target/ENSG00000107831/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3686","ensembl":"ENSG00000107831","uniprot":"P55075","entrez":"2253","biology":"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Location: Secreted (UniProt). Locus 10q24.32 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf8/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}