{"entity":{"id":"fgfr1op2","kind":"target","name":"FGFR1OP2","aka":["FGFR1 oncogene partner 2","DKFZp564O1863"],"tldr":"FGFR1OP2 (FGFR1 oncogene partner 2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia.","summary":"May be involved in wound healing pathway.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.22, affected pathway 0.95, animal model 0.56, genetic association 0.03).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23098"},{"label":"UniProt Q9NVK5","url":"https://www.uniprot.org/uniprotkb/Q9NVK5/entry"},{"label":"NCBI Gene 26127","url":"https://www.ncbi.nlm.nih.gov/gene/26127"},{"label":"Ensembl ENSG00000111790","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111790"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGFR1OP2","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23098","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NVK5","url":"https://www.uniprot.org/uniprotkb/Q9NVK5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000111790","url":"https://platform.opentargets.org/target/ENSG00000111790/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: leukaemia 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:23098","ensembl":"ENSG00000111790","uniprot":"Q9NVK5","entrez":"26127","biology":"May be involved in wound healing pathway. Location: Cytoplasm (UniProt). Locus 12p11.23 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059)"],"targetClass":"other","prevalence":[]},"route":"/targets/fgfr1op2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"}]}}