{"entity":{"id":"flg","kind":"target","name":"FLG","aka":["filaggrin","Filaggrin","FLG1","FLG-1"],"tldr":"FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.","summary":"Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.76, somatic mutation 0.17). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3748","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3748"},{"label":"UniProt P20930","url":"https://www.uniprot.org/uniprotkb/P20930/entry"},{"label":"NCBI Gene 2312","url":"https://www.ncbi.nlm.nih.gov/gene/2312"},{"label":"Ensembl ENSG00000143631","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143631"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","mesothelioma","aml","pleural-mesothelioma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FLG","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3748","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3748","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P20930","url":"https://www.uniprot.org/uniprotkb/P20930/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000143631","url":"https://platform.opentargets.org/target/ENSG00000143631/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.63 (GraphQL API, CC0)"},{"label":"IntOGen FLG","url":"https://www.intogen.org/search?gene=FLG","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3748","ensembl":"ENSG00000143631","uniprot":"P20930","entrez":"2312","biology":"Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt). Locus 1q21.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)","Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/flg/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}