{"entity":{"id":"flumatinib","kind":"drug","name":"Flumatinib","aka":["Xinfu"],"tldr":"Flumatinib is Hansoh Pharma's second-generation BCR-ABL inhibitor, approved in China in 2019 for newly diagnosed chronic-phase chronic myeloid leukaemia.","summary":"Flumatinib is an imatinib derivative developed by Hansoh Pharma. The NMPA approved it in November 2019 for adults with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukaemia in chronic phase, after the FESTnd phase 3 trial reported deeper and faster molecular responses than imatinib. It is the first BCR-ABL inhibitor discovered and developed in China.","status":"approved","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of flumatinib","url":"https://clinicaltrials.gov/search?intr=flumatinib"}],"tags":["china","nmpa-approved"],"related":[],"cancers":["cml"],"sections":[],"technologies":["kinase-inhibitors"],"targets":["bcr-abl"],"drugs":[],"companies":["hansoh-pharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo China deep dive","editedOn":"2026-09-16"},"code":"HH-GV-678","modality":"Oral second-generation BCR-ABL tyrosine kinase inhibitor","mechanism":"Blocks the BCR-ABL fusion kinase that drives chronic myeloid leukaemia, with higher potency than imatinib.","approvals":[{"region":"CN","year":2019,"indication":"Newly diagnosed Philadelphia chromosome-positive chronic myeloid leukaemia, chronic phase"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/flumatinib/","neighbours":{"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"target":[{"id":"bcr-abl","kind":"target","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/targets/bcr-abl/"}],"company":[{"id":"hansoh-pharma","kind":"company","name":"Hansoh Pharmaceutical","route":"/companies/hansoh-pharma/"}]}}