{"entity":{"id":"fmn1","kind":"target","name":"FMN1","aka":["formin 1","Formin-1","DKFZP686C2281","FLJ45135","MGC125288","MGC125289"],"tldr":"FMN1 (Formin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays a role in the formation of adherens junction and the polymerisation of linear actin cables.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, animal model 0.65, genetic association 0.81).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3768","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3768"},{"label":"UniProt Q68DA7","url":"https://www.uniprot.org/uniprotkb/Q68DA7/entry"},{"label":"NCBI Gene 342184","url":"https://www.ncbi.nlm.nih.gov/gene/342184"},{"label":"Ensembl ENSG00000248905","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000248905"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FMN1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3768","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3768","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q68DA7","url":"https://www.uniprot.org/uniprotkb/Q68DA7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000248905","url":"https://platform.opentargets.org/target/ENSG00000248905/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3768","ensembl":"ENSG00000248905","uniprot":"Q68DA7","entrez":"342184","biology":"Plays a role in the formation of adherens junction and the polymerisation of linear actin cables. Location: Nucleus; Cytoplasm; Cell junction, adherens junction; Cell membrane (UniProt). Locus 15q13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fmn1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}