{"entity":{"id":"fndc3b","kind":"target","name":"FNDC3B","aka":["fibronectin type III domain containing 3B","Fibronectin type III domain-containing protein 3B","FAD104","DKFZp762K137","FLJ23399","PRO4979","YVTM2421"],"tldr":"FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.","summary":"May be a positive regulator of adipogenesis.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lymphoid Neoplasm.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24670"},{"label":"UniProt Q53EP0","url":"https://www.uniprot.org/uniprotkb/Q53EP0/entry"},{"label":"NCBI Gene 64778","url":"https://www.ncbi.nlm.nih.gov/gene/64778"},{"label":"Ensembl ENSG00000075420","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075420"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FNDC3B","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:24670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24670","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q53EP0","url":"https://www.uniprot.org/uniprotkb/Q53EP0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FNDC3B","url":"https://www.intogen.org/search?gene=FNDC3B","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:24670","ensembl":"ENSG00000075420","uniprot":"Q53EP0","entrez":"64778","biology":"May be a positive regulator of adipogenesis. Location: Membrane (UniProt). Locus 3q26.31 (HGNC).","whereFound":["Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (LNM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fndc3b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}