{"entity":{"id":"fosb","kind":"target","name":"FOSB","aka":["FosB proto-oncogene, AP-1 transcription factor subunit","G0S3","GOS3","AP-1","MGC42291","DKFZp686C0818"],"tldr":"FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Heterodimerises with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3797","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3797"},{"label":"UniProt P53539","url":"https://www.uniprot.org/uniprotkb/P53539/entry"},{"label":"NCBI Gene 2354","url":"https://www.ncbi.nlm.nih.gov/gene/2354"},{"label":"Ensembl ENSG00000125740","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125740"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Osteoblastoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOSB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3797","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3797","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P53539","url":"https://www.uniprot.org/uniprotkb/P53539/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOSB","url":"https://civicdb.org/features/1956","note":"1 evidence items, 0 assertions, 1 variants; diseases: Osteoblastoma (GraphQL API, CC0)"}],"hgnc":"HGNC:3797","ensembl":"ENSG00000125740","uniprot":"P53539","entrez":"2354","biology":"Heterodimerises with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway. Exhibits transactivation activity in vitro. Involved in the display of nurturing behaviour towards newborns. May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy. Location: Nucleus (UniProt). Locus 19q13.32 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fosb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}