{"entity":{"id":"foxa1","kind":"target","name":"FOXA1","aka":["forkhead box A1","Hepatocyte nuclear factor 3-alpha","HNF3A"],"tldr":"FOXA1 (Hepatocyte nuclear factor 3-alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Breast cancer, Neuroendocrine tumours and 1 more.","summary":"Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Aromatase Inhibitor. Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes affected pathway 0.57, literature 1.00, genetic association 0.26, somatic mutation 0.97, animal model 0.30). IntOGen calls it a driver in 15 cohorts (11 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5021","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5021"},{"label":"UniProt P55317","url":"https://www.uniprot.org/uniprotkb/P55317/entry"},{"label":"NCBI Gene 3169","url":"https://www.ncbi.nlm.nih.gov/gene/3169"},{"label":"Ensembl ENSG00000129514","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000129514"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["prostate","breast-cancer","neuroendocrine","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["er-signaling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 11 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXA1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5021","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5021","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55317","url":"https://www.uniprot.org/uniprotkb/P55317/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXA1","url":"https://civicdb.org/features/2662","note":"1 evidence items, 0 assertions, 1 variants; diseases: Oestrogen Receptor-positive Breast Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000129514","url":"https://platform.opentargets.org/target/ENSG00000129514/associations","note":"association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: prostate cancer 0.73, neuroendocrine neoplasm 0.51, breast cancer 0.72 (GraphQL API, CC0)"},{"label":"IntOGen FOXA1","url":"https://www.intogen.org/search?gene=FOXA1","note":"driver in 15 cohorts (Act 11, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5021","ensembl":"ENSG00000129514","uniprot":"P55317","entrez":"3169","biology":"Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in oestrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Location: Nucleus (UniProt). Locus 14q21.1 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.73 with prostate cancer (MONDO_0008315); IntOGen driver in 11 cohorts (PRAD)","Breast cancer: Open Targets association 0.72 with breast cancer (MONDO_0007254); IntOGen driver in 4 cohorts (BRCA)","Neuroendocrine tumours: Open Targets association 0.51 with neuroendocrine neoplasm (MONDO_0019496)","HR-positive / HER2-negative breast cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/foxa1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"pathway":[{"id":"er-signaling","kind":"pathway","name":"Oestrogen receptor signalling","route":"/pathways/er-signaling/"}]}}