{"entity":{"id":"foxa2","kind":"target","name":"FOXA2","aka":["forkhead box A2","Hepatocyte nuclear factor 3-beta","HNF3B"],"tldr":"FOXA2 (Hepatocyte nuclear factor 3-beta) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5022","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5022"},{"label":"UniProt Q9Y261","url":"https://www.uniprot.org/uniprotkb/Q9Y261/entry"},{"label":"NCBI Gene 3170","url":"https://www.ncbi.nlm.nih.gov/gene/3170"},{"label":"Ensembl ENSG00000125798","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125798"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXA2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:5022","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5022","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y261","url":"https://www.uniprot.org/uniprotkb/Q9Y261/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FOXA2","url":"https://www.intogen.org/search?gene=FOXA2","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5022","ensembl":"ENSG00000125798","uniprot":"Q9Y261","entrez":"3170","biology":"Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Location: Nucleus; Cytoplasm (UniProt). Locus 20p11.21 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/foxa2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}