{"entity":{"id":"foxc2","kind":"target","name":"FOXC2","aka":["forkhead box C2","Forkhead box protein C2","MFH-1","FKHL14"],"tldr":"FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Transcriptional activator.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3801","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3801"},{"label":"UniProt Q99958","url":"https://www.uniprot.org/uniprotkb/Q99958/entry"},{"label":"NCBI Gene 2303","url":"https://www.ncbi.nlm.nih.gov/gene/2303"},{"label":"Ensembl ENSG00000176692","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000176692"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXC2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3801","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3801","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99958","url":"https://www.uniprot.org/uniprotkb/Q99958/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXC2","url":"https://civicdb.org/features/1920","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:3801","ensembl":"ENSG00000176692","uniprot":"Q99958","entrez":"2303","biology":"Transcriptional activator. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/foxc2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}