{"entity":{"id":"foxl2","kind":"target","name":"FOXL2","aka":["forkhead box L2","Forkhead box protein L2","BPES1"],"tldr":"FOXL2 (Forkhead box protein L2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Ovarian Epithelial Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1092","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1092"},{"label":"UniProt P58012","url":"https://www.uniprot.org/uniprotkb/P58012/entry"},{"label":"NCBI Gene 668","url":"https://www.ncbi.nlm.nih.gov/gene/668"},{"label":"Ensembl ENSG00000183770","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183770"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Granulosa Cell Tumour; Ovarian Sex-cord Stromal Tumour; Adult-type Granulosa Cell Tumour Of The Ovary."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXL2","role":["oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1092","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1092","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P58012","url":"https://www.uniprot.org/uniprotkb/P58012/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXL2","url":"https://civicdb.org/features/72","note":"4 evidence items, 0 assertions, 1 variants; diseases: Granulosa Cell Tumour, Ovarian Sex-cord Stromal Tumour, Adult-type Granulosa Cell Tumour Of The Ovary (GraphQL API, CC0)"},{"label":"IntOGen FOXL2","url":"https://www.intogen.org/search?gene=FOXL2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1092","ensembl":"ENSG00000183770","uniprot":"P58012","entrez":"668","biology":"Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Location: Nucleus (UniProt). Locus 3q22.3 (HGNC).","whereFound":["Ovarian cancer: IntOGen driver in 1 cohort (OVT)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/foxl2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}