{"entity":{"id":"foxo1","kind":"target","name":"FOXO1","aka":["forkhead box O1","Forkhead box protein O1","FKH1","FOXO1A"],"tldr":"FOXO1 (Forkhead box protein O1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Non-Hodgkin lymphoma, Ovarian cancer and 4 more.","summary":"Transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.26, literature 0.99, genetic association 0.38, somatic mutation 0.83). IntOGen calls it a driver in 6 cohorts (5 activating, 1 loss-of-function), covering Burkitt Lymphoma, Lung Squamous Cell Carcinoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3819","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3819"},{"label":"UniProt Q12778","url":"https://www.uniprot.org/uniprotkb/Q12778/entry"},{"label":"NCBI Gene 2308","url":"https://www.ncbi.nlm.nih.gov/gene/2308"},{"label":"Ensembl ENSG00000150907","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150907"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["sarcoma","non-hodgkin-lymphoma","ovarian","rhabdomyosarcoma","dlbcl","burkitt-lymphoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXO1","role":["oncogene-driver","tumour-suppressor","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3819","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3819","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q12778","url":"https://www.uniprot.org/uniprotkb/Q12778/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXO1","url":"https://civicdb.org/features/1925","note":"2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000150907","url":"https://platform.opentargets.org/target/ENSG00000150907/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: ovarian cancer 0.50, sarcoma 0.65, non-Hodgkin lymphoma 0.58, rhabdomyosarcoma 0.62 (GraphQL API, CC0)"},{"label":"IntOGen FOXO1","url":"https://www.intogen.org/search?gene=FOXO1","note":"driver in 6 cohorts (Act 5, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3819","ensembl":"ENSG00000150907","uniprot":"Q12778","entrez":"2308","biology":"Transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Location: Cytoplasm; Nucleus (UniProt). Locus 13q14.11 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.65 with sarcoma (MONDO_0005089)","Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (MLYM, NHL)","Ovarian cancer: Open Targets association 0.50 with ovarian cancer (MONDO_0008170)","Rhabdomyosarcoma: Open Targets association 0.62 with rhabdomyosarcoma (MONDO_0005212)","Diffuse large B-cell lymphoma: CIViC evidence names this disease","Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 2 cohorts (BL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/foxo1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"rhabdomyosarcoma","kind":"cancer","name":"Rhabdomyosarcoma","route":"/cancers/rhabdomyosarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}