{"entity":{"id":"foxp4","kind":"target","name":"FOXP4","aka":["forkhead box P4","Forkhead box protein P4","FLJ40908"],"tldr":"FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcriptional repressor that represses lung-specific expression.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.61, somatic mutation 0.28).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20842"},{"label":"UniProt Q8IVH2","url":"https://www.uniprot.org/uniprotkb/Q8IVH2/entry"},{"label":"NCBI Gene 116113","url":"https://www.ncbi.nlm.nih.gov/gene/116113"},{"label":"Ensembl ENSG00000137166","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137166"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXP4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:20842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20842","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IVH2","url":"https://www.uniprot.org/uniprotkb/Q8IVH2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137166","url":"https://platform.opentargets.org/target/ENSG00000137166/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:20842","ensembl":"ENSG00000137166","uniprot":"Q8IVH2","entrez":"116113","biology":"Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt). Locus 6p21.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/foxp4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}