{"entity":{"id":"francesco-lo-coco","kind":"person","name":"Francesco Lo-Coco","aka":[],"tldr":"Italian haematologist who led APL0406, the trial that showed acute promyelocytic leukaemia can be cured with all-trans retinoic acid and arsenic trioxide alone, without chemotherapy.","summary":"Francesco Lo-Coco was professor of haematology at the University of Rome Tor Vergata and a leading investigator of the Italian GIMEMA group. He was first author of the 2013 New England Journal of Medicine report of APL0406, the Italian-German trial that showed all-trans retinoic acid plus arsenic trioxide was at least as effective as ATRA plus chemotherapy in low- and intermediate-risk acute promyelocytic leukaemia, with far fewer haematological complications. The chemotherapy-free regimen became the standard of care. He died in 2019.","asOf":"2026-09-18","links":[],"tags":["leukaemia","trialist"],"related":[],"cancers":["apl","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["apl0406"],"people":[],"bottlenecks":[],"keyPapers":["paper-apl0406-lo-coco-nejm-2013"],"journals":[],"dependsOn":[],"notes":[],"role":"Haematologist, University of Rome Tor Vergata (died 2019)","specialisms":["Acute promyelocytic leukaemia","Arsenic trioxide","Molecular monitoring"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lo-Coco%5BAuthor%5D"}],"papers":[]},"route":"/people/francesco-lo-coco/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"apl","kind":"cancer","name":"Acute promyelocytic leukaemia","route":"/cancers/apl/"}],"trial":[{"id":"apl0406","kind":"trial","name":"APL0406","route":"/trials/apl0406/"}],"paper":[{"id":"paper-apl0406-lo-coco-nejm-2013","kind":"paper","name":"APL0406: retinoic acid plus arsenic trioxide without chemotherapy for low- and intermediate-risk acute promyelocytic leukaemia","route":"/key-papers/paper-apl0406-lo-coco-nejm-2013/"}]}}