{"entity":{"id":"frs2","kind":"target","name":"FRS2","aka":["fibroblast growth factor receptor substrate 2","Fibroblast growth factor receptor substrate 2","SNT-1","FRS2alpha","SNT1","FRS2A"],"tldr":"FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.90, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16971","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16971"},{"label":"UniProt Q8WU20","url":"https://www.uniprot.org/uniprotkb/Q8WU20/entry"},{"label":"NCBI Gene 10818","url":"https://www.ncbi.nlm.nih.gov/gene/10818"},{"label":"Ensembl ENSG00000166225","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166225"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["fgfr-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FRS2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16971","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16971","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WU20","url":"https://www.uniprot.org/uniprotkb/Q8WU20/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166225","url":"https://platform.opentargets.org/target/ENSG00000166225/associations","note":"association with cancer (MONDO_0004992) 0.65;  (GraphQL API, CC0)"}],"hgnc":"HGNC:16971","ensembl":"ENSG00000166225","uniprot":"Q8WU20","entrez":"10818","biology":"Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1. Location: Endomembrane system (UniProt). Locus 12q15 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/frs2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"fgfr-signalling","kind":"pathway","name":"FGF / FGFR signalling","route":"/pathways/fgfr-signalling/"}]}}