{"entity":{"id":"frs3","kind":"target","name":"FRS3","aka":["fibroblast growth factor receptor substrate 3","Fibroblast growth factor receptor substrate 3","SNT-2","FRS2beta","FRS2B"],"tldr":"FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.76, genetic association 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16970","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16970"},{"label":"UniProt O43559","url":"https://www.uniprot.org/uniprotkb/O43559/entry"},{"label":"NCBI Gene 10817","url":"https://www.ncbi.nlm.nih.gov/gene/10817"},{"label":"Ensembl ENSG00000137218","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137218"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FRS3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16970","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16970","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43559","url":"https://www.uniprot.org/uniprotkb/O43559/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137218","url":"https://platform.opentargets.org/target/ENSG00000137218/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:16970","ensembl":"ENSG00000137218","uniprot":"O43559","entrez":"10817","biology":"Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2. Location: Membrane (UniProt). Locus 6p21.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/frs3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}