{"entity":{"id":"fubp1","kind":"target","name":"FUBP1","aka":["far upstream element binding protein 1","Far upstream element-binding protein 1"],"tldr":"FUBP1 (Far upstream element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 2 more.","summary":"Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.54, somatic mutation 0.77). IntOGen calls it a driver in 4 cohorts (2 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Low-Grade Glioma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4004","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4004"},{"label":"UniProt Q96AE4","url":"https://www.uniprot.org/uniprotkb/Q96AE4/entry"},{"label":"NCBI Gene 8880","url":"https://www.ncbi.nlm.nih.gov/gene/8880"},{"label":"Ensembl ENSG00000162613","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162613"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["skin-cancer","breast-cancer","colorectal","lung-cancer","cll"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oligodendroglioma; Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FUBP1","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4004","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4004","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96AE4","url":"https://www.uniprot.org/uniprotkb/Q96AE4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FUBP1","url":"https://civicdb.org/features/7044","note":"1 evidence items, 0 assertions, 1 variants; diseases: Oligodendroglioma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000162613","url":"https://platform.opentargets.org/target/ENSG00000162613/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.54, skin cancer 0.61, lung cancer 0.50 (GraphQL API, CC0)"},{"label":"IntOGen FUBP1","url":"https://www.intogen.org/search?gene=FUBP1","note":"driver in 4 cohorts (Act 2, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4004","ensembl":"ENSG00000162613","uniprot":"Q96AE4","entrez":"8880","biology":"Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Location: Nucleus (UniProt). Locus 1p31.1 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.61 with skin cancer (MONDO_0002898)","Breast cancer: IntOGen driver in 1 cohort (BRCA)","Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)","Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/fubp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}