{"entity":{"id":"fus","kind":"target","name":"FUS","aka":["FUS RNA binding protein","RNA-binding protein FUS","FUS1","hnRNP-P2","HNRNPP2","ALS6"],"tldr":"FUS (RNA-binding protein FUS) is a gene. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Hepatocellular carcinoma and Liposarcoma.","summary":"DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, animal model 0.38, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4010"},{"label":"UniProt P35637","url":"https://www.uniprot.org/uniprotkb/P35637/entry"},{"label":"NCBI Gene 2521","url":"https://www.ncbi.nlm.nih.gov/gene/2521"},{"label":"Ensembl ENSG00000089280","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000089280"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["sarcoma","hcc","liposarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["blood-brain-barrier-metastasis"],"terms":[],"trials":["nct06496971"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FUS","role":["fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4010","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35637","url":"https://www.uniprot.org/uniprotkb/P35637/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000089280","url":"https://platform.opentargets.org/target/ENSG00000089280/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: sarcoma 0.61, liposarcoma 0.56 (GraphQL API, CC0)"},{"label":"IntOGen FUS","url":"https://www.intogen.org/search?gene=FUS","note":"driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4010","ensembl":"ENSG00000089280","uniprot":"P35637","entrez":"2521","biology":"DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. Location: Nucleus (UniProt). Locus 16p11.2 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Liposarcoma: Open Targets association 0.56 with liposarcoma (MONDO_0005060)"],"targetClass":"other","prevalence":[]},"route":"/targets/fus/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"pathway":[{"id":"blood-brain-barrier-metastasis","kind":"pathway","name":"The blood-brain barrier & brain metastasis","route":"/pathways/blood-brain-barrier-metastasis/"}],"trial":[{"id":"nct06496971","kind":"trial","name":"A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients","route":"/trials/nct06496971/"}]}}