{"entity":{"id":"fx-111","kind":"drug","name":"FX-111","aka":[],"tldr":"FX-111 is an experimental protein degrader from Flare Therapeutics, in phase 1 trials for metastatic castration-resistant prostate cancer.","summary":"FX-111 is a degrader (the company describes its molecules as small molecules) from Flare Therapeutics. A selective degrader of the active, hormone-bound form of the androgen receptor, which the company calls AR ON. The phase 1 study NCT07719361, which started in July 2026, is recruiting. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"Flare Therapeutics FX-111","url":"https://www.flaretx.com/pipeline/fx-111/"},{"label":"ClinicalTrials.gov NCT07719361","url":"https://clinicaltrials.gov/study/NCT07719361"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["prostate-mcrpc"],"sections":[],"technologies":[],"targets":["androgen-receptor"],"drugs":[],"companies":["flare-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07719361"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"FX-111","modality":"Degrader (the company describes its molecules as small molecules)","mechanism":"A selective degrader of the active, hormone-bound form of the androgen receptor, which the company calls AR ON.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/fx-111/","neighbours":{"cancer":[{"id":"prostate-mcrpc","kind":"cancer","name":"Metastatic castration-resistant prostate cancer","route":"/cancers/prostate-mcrpc/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"}],"company":[{"id":"flare-therapeutics","kind":"company","name":"Flare Therapeutics","route":"/companies/flare-therapeutics/"}],"trial":[{"id":"nct07719361","kind":"trial","name":"A Study in Patients With Metastatic Castration-Resistant Prostate Cancer","route":"/trials/nct07719361/"}]}}