{"entity":{"id":"gab2","kind":"target","name":"GAB2","aka":["GRB2 associated binding protein 2","GRB2-associated-binding protein 2","KIAA0571"],"tldr":"GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.","summary":"Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.84, animal model 0.41, genetic association 0.47).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14458"},{"label":"UniProt Q9UQC2","url":"https://www.uniprot.org/uniprotkb/Q9UQC2/entry"},{"label":"NCBI Gene 9846","url":"https://www.ncbi.nlm.nih.gov/gene/9846"},{"label":"Ensembl ENSG00000033327","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000033327"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","cml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["bcr-abl1-signalling","cml-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GAB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14458","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UQC2","url":"https://www.uniprot.org/uniprotkb/Q9UQC2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000033327","url":"https://platform.opentargets.org/target/ENSG00000033327/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: chronic myelogenous leukaemia, BCR-ABL1 positive 0.54, myeloproliferative neoplasm 0.59, leukaemia 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:14458","ensembl":"ENSG00000033327","uniprot":"Q9UQC2","entrez":"9846","biology":"Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and haematopoiesis. Location: Cytoplasm; Cell membrane; Membrane raft (UniProt). Locus 11q14.1 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076)","Chronic myeloid leukaemia: Open Targets association 0.54 with chronic myelogenous leukaemia, BCR-ABL1 positive (MONDO_0011996)"],"targetClass":"other","prevalence":[]},"route":"/targets/gab2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}],"pathway":[{"id":"bcr-abl1-signalling","kind":"pathway","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/pathways/bcr-abl1-signalling/"},{"id":"cml-signalling","kind":"pathway","name":"Chronic myeloid leukaemia (KEGG map)","route":"/pathways/cml-signalling/"}]}}