{"entity":{"id":"gadd45a","kind":"target","name":"GADD45A","aka":["growth arrest and DNA damage inducible alpha","Growth arrest and DNA damage-inducible protein GADD45 alpha","GADD45","DDIT1"],"tldr":"GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4095","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4095"},{"label":"UniProt P24522","url":"https://www.uniprot.org/uniprotkb/P24522/entry"},{"label":"NCBI Gene 1647","url":"https://www.ncbi.nlm.nih.gov/gene/1647"},{"label":"Ensembl ENSG00000116717","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116717"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt keyword \"DNA damage\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GADD45A","role":["biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4095","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4095","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P24522","url":"https://www.uniprot.org/uniprotkb/P24522/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GADD45A","url":"https://civicdb.org/features/1411","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:4095","ensembl":"ENSG00000116717","uniprot":"P24522","entrez":"1647","biology":"In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Location: Nucleus (UniProt). Locus 1p31.3 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/gadd45a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}